Hoxc6-flox 基因敲除小鼠

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产品名称

Hoxc6-flox 基因敲除小鼠

产品编号

S-CKO-02949

品系全称

C57BL/6JCya-Hoxc6em1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-15425-Hoxc6-B6J-VA

品系状态

使用本品系发表的文献需注明: Hoxc6-flox 基因敲除小鼠 mice (Strain S-CKO-02949) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
homeobox C6
基因别称
Hox-3.3,Hox-6.1
染色体号
Chr 15 (Mouse)
转录本 ID
NCBI: NM_010465 | Ensembl: ENSMUST00000001711
修饰方式
条件性基因敲除
靶向范围
Exon 1~2
敲除长度
~2.3 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:96197Mice homozygous for disruptions in this gene display a transformation of thoracic vertebra 2 to a form similar to that of T1. Mammary glands do not develop normally resulting in poor lactation and poor survival of pups.
Hoxc6基因属于同源盒基因家族,编码的蛋白含有同源结构域,是一种重要的转录因子。Hoxc6基因在多种生物学过程中发挥着关键作用,包括胚胎发育、细胞分化和肿瘤发生。Hoxc6基因的表达受到多种因素的调控,包括发育阶段、细胞类型和环境因素。Hoxc6基因的突变或表达异常与多种疾病的发生和发展密切相关。

Hoxc6基因在肿瘤发生中发挥着重要作用。多项研究表明,Hoxc6基因在多种肿瘤组织中高表达,包括胶质瘤、宫颈癌、乳腺癌、胃癌和肝癌等。Hoxc6基因的高表达与肿瘤的发生、发展和预后密切相关。例如,Hoxc6基因在胶质瘤中的高表达与肿瘤的侵袭性、免疫微环境和患者的不良预后相关。Hoxc6基因可能通过调控上皮-间质转化(EMT)信号通路和免疫微环境来促进胶质瘤的发生和发展。此外,Hoxc6基因在宫颈癌、乳腺癌、胃癌和肝癌中的高表达也与肿瘤的侵袭性、细胞增殖和患者的不良预后相关。

Hoxc6基因的调控机制也是研究的热点之一。研究表明,Hoxc6基因的表达受到多种因素的调控,包括转录因子、表观遗传调控和信号通路。例如,TGF-β/Smad信号通路可以调控Hoxc6基因的表达,进而影响肿瘤的发生和发展。此外,Hoxc6基因的表达还可以受到雌激素和双酚A等环境因素的影响。

综上所述,Hoxc6基因在肿瘤发生中发挥着重要作用,其高表达与肿瘤的侵袭性、细胞增殖和患者的不良预后相关。Hoxc6基因的调控机制复杂,受到多种因素的调控。深入研究Hoxc6基因的功能和调控机制,有助于揭示肿瘤发生和发展的分子机制,为肿瘤的治疗和预防提供新的思路和策略[1][2][3][4][5][6][7][8][9][10]。

参考文献:
1. Huang, Hui, Huo, Zhengyuan, Jiao, Jiantong, Shao, Junfei, Sun, Jun. 2022. HOXC6 impacts epithelial-mesenchymal transition and the immune microenvironment through gene transcription in gliomas. In Cancer cell international, 22, 170. doi:10.1186/s12935-022-02589-9. https://pubmed.ncbi.nlm.nih.gov/35488304/
2. Zhang, Feng, Ren, Chen-Chen, Liu, Ling, Yang, Li, Zhang, Xiao-An. 2018. HOXC6 gene silencing inhibits epithelial-mesenchymal transition and cell viability through the TGF-β/smad signaling pathway in cervical carcinoma cells. In Cancer cell international, 18, 204. doi:10.1186/s12935-018-0680-2. https://pubmed.ncbi.nlm.nih.gov/30559605/
3. Chariot, A, Gielen, J. . The HOXC6 homeodomain-containing proteins. In The international journal of biochemistry & cell biology, 30, 651-5. doi:. https://pubmed.ncbi.nlm.nih.gov/9695021/
4. Hu, Lingzhu, Zhang, Shun, Zhou, Yu, Xu, Shanliang, Wang, Danli. 2020. Cloning and expression of Hoxc6 gene from Pampus argenteus and its relationship with pelvic fin absence. In Gene expression patterns : GEP, 39, 119161. doi:10.1016/j.gep.2020.119161. https://pubmed.ncbi.nlm.nih.gov/33309862/
5. Hussain, Imran, Bhan, Arunoday, Ansari, Khairul I, Perrotti, Linda I, Mandal, Subhrangsu S. 2015. Bisphenol-A induces expression of HOXC6, an estrogen-regulated homeobox-containing gene associated with breast cancer. In Biochimica et biophysica acta, 1849, 697-708. doi:10.1016/j.bbagrm.2015.02.003. https://pubmed.ncbi.nlm.nih.gov/25725483/
6. Chen, Shi-Wei, Zhang, Qing, Xu, Zhi-Feng, Wang, Ping, Li, Yong. 2016. HOXC6 promotes gastric cancer cell invasion by upregulating the expression of MMP9. In Molecular medicine reports, 14, 3261-8. doi:10.3892/mmr.2016.5640. https://pubmed.ncbi.nlm.nih.gov/27573865/
7. Li, Pin-Dong, Chen, Peng, Peng, Xin, Zhang, Wen-Jie, Dai, Xiao-Fang. . HOXC6 predicts invasion and poor survival in hepatocellular carcinoma by driving epithelial-mesenchymal transition. In Aging, 10, 115-130. doi:10.18632/aging.101363. https://pubmed.ncbi.nlm.nih.gov/29348394/
8. Eryi, Sun, Zheng, Li, Honghua, Cai, Liping, Zhan, Bo, Chen. 2022. HOXC6 Regulates the Epithelial-Mesenchymal Transition through the TGF-β/Smad Signaling Pathway and Predicts a Poor Prognosis in Glioblastoma. In Journal of oncology, 2022, 8016102. doi:10.1155/2022/8016102. https://pubmed.ncbi.nlm.nih.gov/35571491/
9. Zhou, Junyu, Yang, Xiaogang, Song, Peng, Wang, Hongwei, Wang, Xiumei. . HOXC6 in the prognosis of prostate cancer. In Artificial cells, nanomedicine, and biotechnology, 47, 2715-2720. doi:10.1080/21691401.2019.1635136. https://pubmed.ncbi.nlm.nih.gov/31271305/
10. Wang, Yongsheng, Wang, Cong, Liu, Na, Xiao, Wenjing, Wang, Hui. 2018. HOXC6 promotes cervical cancer progression via regulation of Bcl-2. In FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33, 3901-3911. doi:10.1096/fj.201801099RR. https://pubmed.ncbi.nlm.nih.gov/30509141/