智鼠故事 
Hmga1-flox 基因敲除小鼠
复苏/繁育服务
产品名称
Hmga1-flox 基因敲除小鼠
产品编号
S-CKO-02909
品系全称
C57BL/6JCya-Hmga1em1flox/Cya
品系背景
C57BL/6JCya
品系编号
CKOCMP-15361-Hmga1-B6J-VA
品系状态
使用本品系发表的文献需注明： Hmga1-flox 基因敲除小鼠 mice (Strain S-CKO-02909) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因别称
Hmgi，Hmgy，Hmgiy，Hmga1a，Hmga1b
NCBI ID
染色体号
Chr 17
NCBI RefSeq
NM_001166546
Ensembl ID
ENSMUST00000231866
修饰方式
条件性基因敲除
靶向范围
Exon 2~4
敲除长度
~2.5 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:96160Although haploinsufficiency at this locus is not compatible with germline transmission of one allele at this locus, mice homozygous for two other disruptions are fertile. Abnormalities are seen in glucose metabolism and in the cardiovascular system.
发表文献
Nature Communications
2024-11-15
High mobility group A1 (HMGA1) promotes the tumorigenesis of colorectal cancer by increasing lipid synthesis
Cell Death & Disease
2024-07-30
HMGA1 promotes the progression of esophageal squamous cell carcinoma by elevating TKT-mediated upregulation of pentose phosphate pathway
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