Ctse-flox 基因敲除小鼠

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产品名称

Ctse-flox 基因敲除小鼠

产品编号

S-CKO-01937

品系全称

C57BL/6JCya-Ctseem1flox/Cya

品系背景

C57BL/6JCya

品系编号

CKOCMP-13034-Ctse-B6J-VA

品系状态

使用本品系发表的文献需注明: Ctse-flox 基因敲除小鼠 mice (Strain S-CKO-01937) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
cKO小鼠库模型

基本信息

基因研究概述

质控标准

基因
基因全称
cathepsin E
基因别称
A430072O03Rik,C920004C08Rik,CE,CatE
染色体号
Chr 1 (Mouse)
转录本 ID
NCBI: NM_007799 | Ensembl: ENSMUST00000073350
修饰方式
条件性基因敲除
靶向范围
Exon 5
敲除长度
~0.6 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成,建议您在购买前查询最新的数据库和相关文献,以获取最准确的表型信息。
表型提示
MGI:107361Mice homozygous for a targeted mutation are viable and fertile, but develop skin lesions on the face, ears, neck and dorsal skin which are similar to those seen in human atopic dermatitis.
基因CTSE,也称为组织蛋白酶E,是一种重要的天冬氨酸蛋白酶。它在多种生物学过程中发挥作用,包括抗原呈递、细胞内消化、细胞凋亡、细胞迁移和肿瘤发生。CTSE的表达和活性与多种疾病的发生和发展密切相关,包括癌症、炎症性疾病和神经退行性疾病。

CTSE在癌症中的作用是一个研究热点。多项研究表明,CTSE的表达水平与多种癌症的预后相关。例如,在膀胱癌中,CTSE的表达水平与患者的生存期和化疗敏感性相关。在肝细胞癌中,CTSE的表达水平与患者的预后不良相关。在结直肠癌中,CTSE的表达水平与患者的化疗耐药性相关。这些研究表明,CTSE可能是一个有潜力的癌症治疗靶点。

CTSE的表达和活性受多种因素的调控。例如,转录因子Kaiso可以结合到CTSE基因启动子区的mCGCG序列,抑制CTSE的表达。此外,CTSE的表达还受DNA甲基化状态的调控。在系统性红斑狼疮中,CD4+细胞的DNA低甲基化导致CTSE的表达上调。

除了在癌症中的作用,CTSE还与炎症性疾病和神经退行性疾病相关。例如,在家族性淀粉样多神经病中,CTSE的表达下调,可能与疾病的发病机制相关。

综上所述,CTSE是一个重要的天冬氨酸蛋白酶,参与多种生物学过程。CTSE的表达和活性与多种疾病的发生和发展密切相关,包括癌症、炎症性疾病和神经退行性疾病。CTSE的研究有助于深入理解这些疾病的发病机制,为疾病的治疗和预防提供新的思路和策略[1][2][3][4][5][6][7][8][9][10]。

参考文献:
1. Chen, Hualin, Yang, Wenjie, Li, Yingjie, Ma, Lin, Ji, Zhigang. 2023. Leveraging a disulfidptosis-based signature to improve the survival and drug sensitivity of bladder cancer patients. In Frontiers in immunology, 14, 1198878. doi:10.3389/fimmu.2023.1198878. https://pubmed.ncbi.nlm.nih.gov/37325625/
2. Liu, Qi, Chen, Junyi, Liu, Yuyang, Zhang, Ning, Yang, Zhanyu. 2024. The impact of cathepsins on liver hepatocellular carcinoma: Insights from genetic and functional analyses. In Gene, 935, 149064. doi:10.1016/j.gene.2024.149064. https://pubmed.ncbi.nlm.nih.gov/39486661/
3. Blumer, Moritz, Brown, Tom, Freitas, Mariella Bontempo, Lim, Burton K, Hiller, Michael. 2022. Gene losses in the common vampire bat illuminate molecular adaptations to blood feeding. In Science advances, 8, eabm6494. doi:10.1126/sciadv.abm6494. https://pubmed.ncbi.nlm.nih.gov/35333583/
4. Pontious, Corbin, Kaul, Sabrina, Hong, Marcus, Conwell, Darwin L, Cruz-Monserrate, Zobeida. 2019. Cathepsin E expression and activity: Role in the detection and treatment of pancreatic cancer. In Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 19, 951-956. doi:10.1016/j.pan.2019.09.009. https://pubmed.ncbi.nlm.nih.gov/31582345/
5. Chou, Chia-Lin, Chen, Tzu-Ju, Tian, Yu-Feng, Li, Chien-Feng, Lai, Hong-Yue. 2021. CTSE Overexpression Is an Adverse Prognostic Factor for Survival among Rectal Cancer Patients Receiving CCRT. In Life (Basel, Switzerland), 11, . doi:10.3390/life11070646. https://pubmed.ncbi.nlm.nih.gov/34357018/
6. Page, Jeanine L, Strom, Stephen C, Omiecinski, Curtis J. 2007. Regulation of the human cathepsin E gene by the constitutive androstane receptor. In Archives of biochemistry and biophysics, 467, 132-8. doi:. https://pubmed.ncbi.nlm.nih.gov/17888866/
7. Ye, Hua, Li, Tiandong, Wang, Hua, Yu, Yongwei, Li, Jitian. 2021. TSPAN1, TMPRSS4, SDR16C5, and CTSE as Novel Panel for Pancreatic Cancer: A Bioinformatics Analysis and Experiments Validation. In Frontiers in immunology, 12, 649551. doi:10.3389/fimmu.2021.649551. https://pubmed.ncbi.nlm.nih.gov/33815409/
8. Hiramatsu, Sumie, Watanabe, Katsue S, Zeggar, Sonia, Sada, Ken-Ei, Wada, Jun. 2019. Regulation of Cathepsin E gene expression by the transcription factor Kaiso in MRL/lpr mice derived CD4+ T cells. In Scientific reports, 9, 3054. doi:10.1038/s41598-019-38809-y. https://pubmed.ncbi.nlm.nih.gov/30816218/
9. Fisher, Oliver M, Levert-Mignon, Angelique J, Lord, Sarah J, Bobryshev, Yuri V, Lord, Reginald V. 2014. High Expression of Cathepsin E in Tissues but Not Blood of Patients with Barrett's Esophagus and Adenocarcinoma. In Annals of surgical oncology, 22, 2431-8. doi:10.1245/s10434-014-4155-y. https://pubmed.ncbi.nlm.nih.gov/25348778/
10. Gonçalves, Nádia Pereira, Moreira, João, Martins, Diana, Saraiva, Margarida, Saraiva, Maria João. 2017. Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system. In Journal of neuroinflammation, 14, 115. doi:10.1186/s12974-017-0891-9. https://pubmed.ncbi.nlm.nih.gov/28583160/