Ch25h-flox 基因敲除小鼠

1. Ding, Xuexuan, Qin, Jingtong, Huang, Fangfang, Feng, Fuhai, Luo, Lianxiang. 2023. The combination of machine learning and untargeted metabolomics identifies the lipid metabolism -related gene CH25H as a potential biomarker in asthma. In Inflammation research : official journal of the European Histamine Research Society ... [et al.], 72, 1099-1119. doi:10.1007/s00011-023-01732-0. https://pubmed.ncbi.nlm.nih.gov/37081162/

2. Xiao, Jun, Wang, Shuang, Chen, Longlong, Wei, Bin, Wang, Hongyan. 2024. 25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages. In Immunity, 57, 1087-1104.e7. doi:10.1016/j.immuni.2024.03.021. https://pubmed.ncbi.nlm.nih.gov/38640930/

3. Lu, Zhen, McBrearty, Noreen, Chen, Jinyun, Koumenis, Constantinos, Fuchs, Serge Y. . ATF3 and CH25H regulate effector trogocytosis and anti-tumor activities of endogenous and immunotherapeutic cytotoxic T lymphocytes. In Cell metabolism, 34, 1342-1358.e7. doi:10.1016/j.cmet.2022.08.007. https://pubmed.ncbi.nlm.nih.gov/36070682/

4. Canfrán-Duque, Alberto, Rotllan, Noemi, Zhang, Xinbo, Fernández-Hernando, Carlos, Suárez, Yajaira. 2022. Macrophage-Derived 25-Hydroxycholesterol Promotes Vascular Inflammation, Atherogenesis, and Lesion Remodeling. In Circulation, 147, 388-408. doi:10.1161/CIRCULATIONAHA.122.059062. https://pubmed.ncbi.nlm.nih.gov/36416142/

5. Toral-Rios, Danira, Long, Justin M, Ulrich, Jason D, Cashikar, Anil G, Paul, Steven M. 2024. Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. In The Journal of experimental medicine, 221, . doi:10.1084/jem.20232000. https://pubmed.ncbi.nlm.nih.gov/38442267/

6. Zhang, Jun, Xu, Lidong, Gao, Jun, Gong, Ziying, Zhang, Daoyun. 2022. Leukocyte CH25H is a potential diagnostic and prognostic marker for lung adenocarcinoma. In Scientific reports, 12, 22201. doi:10.1038/s41598-022-24183-9. https://pubmed.ncbi.nlm.nih.gov/36564433/

7. Xie, Tingting, Feng, Min, Zhang, Xi, Shi, Meiqing, Zhang, Xiquan. 2023. Chicken CH25H inhibits ALV-J replication by promoting cellular autophagy. In Frontiers in immunology, 14, 1093289. doi:10.3389/fimmu.2023.1093289. https://pubmed.ncbi.nlm.nih.gov/36875122/

8. Dong, Zeyu, He, Fangzhou, Yan, Xiaosong, Yuan, Zuyi, Y-J Shyy, John. 2022. Hepatic Reduction in Cholesterol 25-Hydroxylase Aggravates Diet-induced Steatosis. In Cellular and molecular gastroenterology and hepatology, 13, 1161-1179. doi:10.1016/j.jcmgh.2021.12.018. https://pubmed.ncbi.nlm.nih.gov/34990887/

9. McBrearty, Noreen, Cho, Christina, Chen, Jinyun, Rui, Hallgeir, Fuchs, Serge Y. . Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells. In Molecular cancer research : MCR, 21, 228-239. doi:10.1158/1541-7786.MCR-22-0602. https://pubmed.ncbi.nlm.nih.gov/36378658/

10. Zhang, Jialiang, Zhou, Hao, Lei, Fan, Huang, Fangyang, Chen, Mao. 2024. Cholesterol 25-hydroxylase prevents type 2 diabetes mellitus induced cardiomyopathy by alleviating cardiac lipotoxicity. In Biochimica et biophysica acta. Molecular basis of disease, 1870, 167158. doi:10.1016/j.bbadis.2024.167158. https://pubmed.ncbi.nlm.nih.gov/38588780/