智鼠故事 
C57BL/6NCya-Ahrem1flox/Cya 条件性基因敲除小鼠
复苏/繁育服务
产品名称
Ahr-flox
产品编号
S-CKO-01108
品系全称
C57BL/6NCya-Ahrem1flox/Cya
品系背景
C57BL/6NCya
品系编号
CKOCMP-11622-Ahr-B6N-VA
品系状态
使用本品系发表的文献需注明： Ahr-flox mice (Strain S-CKO-01108) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
基因
基因别称
Ah，In，Ahh，Ahre，bHLHe76
NCBI ID
染色体号
Chr 12
NCBI RefSeq
NM_013464
Ensembl ID
ENSMUST00000116436
修饰方式
条件性基因敲除
靶向范围
Exon 5~7
敲除长度
~3.8 kb
品系说明
该品系是基于策略设计时的数据库信息制作而成，建议您在购买前查询最新的数据库和相关文献，以获取最准确的表型信息。
表型提示
MGI:105043Homozygotes for null or hypomorphic alleles do not respond to cyclic compounds (e.g., dioxin) and are resistant to their teratogenic effects. Depending on the allele, null mutants may also have liver defects, impaired female fertility, neonatal or postnatal lethality, and spleen abnormalities. Conditional homozygous KO in the retina leads to retinal degeneration. Conditional KO in neural progenitor cells leads to decreased susceptibility to ischemic brain injury.
发表文献
npj Regenerative Medicine
2023-11-08
Aryl hydrocarbon receptor regulates IL-22 receptor expression on thymic epithelial cell and accelerates thymus regeneration
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