智鼠故事 
KP 小鼠
复苏/繁育服务
自发肿瘤模型
* 使用本品系发表的文献需注明：KP 小鼠 mice (Catalog C001320) were purchased from Cyagen.
交付类型
周龄
性别
基因型
数量
只
基本信息
产品名称
KP 小鼠
产品编号
C001320
基因别称
ras；p21B；K-Ras；K-ras；Kras2；Ki-ras；Kras-2；K-Ras 2；c-K-ras；c-Ki-ras ; bbl；bfy；bhy；p44；p53；Tp53
模型分类
自发肿瘤模型
染色体
6
更多信息
* 使用本品系发表的文献需注明：KP 小鼠 mice (Catalog C001320) were purchased from Cyagen.
品系描述
本模型携带LSL-Kras G12D和LSL-Trp53 R172H两种基因型。Kras G12D是人类肿瘤中常见的Kras基因的活化突变体，Trp53 R172H是p53基因的突变体。分别在这两个基因编码区和启动子之间插入Loxp-Stop-Loxp终止序列，然后将这两个基因构件转入小鼠基因组，制作出双基因型KP小鼠。由于Loxp-Stop-Loxp终止序列的存在，这两个基因在没有Cre重组酶的条件下不表达突变蛋白；当与组织特异性表达的Cre交配后，可导致转录终止序列（Loxp-Stop-Loxp）缺失进而表达致癌蛋白。杂合子是可存活且可育的。
相关疾病：
Schimmelpenning-Feuerstein-Mims Syndrome
Oculoectodermal Syndrome
Cardiofaciocutaneous Syndrome 2
Noonan Syndrome 3
Arteriovenous Malformations of the Brain
Ras-Associated Autoimmune Leukoproliferative Disorder
Pancreatic Cancer
Gastric Cancer
Lung Cancer
Juvenile Myelomonocytic Leukemia
Bladder Cancer
Noonan Syndrome 1
Cardiofaciocutaneous Syndrome 1
Lung Sarcomatoid Carcinoma
Leukemia, Acute Myeloid
Lung Cancer Susceptibility 3
Encephalocraniocutaneous Lipomatosis
Lung Squamous Cell Carcinoma
Plasma Cell Neoplasm
Pilocytic Astrocytoma
Thyroid Cancer
Rasopathy
Diffuse Gastric and Lobular Breast Cancer Syndrome
Pseudo-Turner Syndrome
Breast Adenocarcinoma
Chronic Myelogenous Leukemia, Bcr-Abl1 Positive
Myeloma, Multiple
Gallbladder Cancer
Leukemia, Chronic Myeloid
Adenoid Cystic Carcinoma
Capillary Malformation-Arteriovenous Malformation 1
Nevus, Epidermal
Pilomyxoid Astrocytoma
Noonan Syndrome and Noonan-Related Syndrome
Differentiated Thyroid Carcinoma
Ovarian Cancer
Pancreatic Adenocarcinoma
Angiosarcoma
Thyroid Gland Medullary Carcinoma
Thyroid Carcinoma, Familial Medullary
Lynch Syndrome
Bladder Urothelial Carcinoma
Gastrointestinal Stromal Tumor
Skin Melanoma
Gastric Adenocarcinoma
Esophageal Cancer
Hereditary Breast Ovarian Cancer Syndrome
Leukemia, Chronic Lymphocytic
Hepatocellular Carcinoma
Li-Fraumeni Syndrome
Papilloma of Choroid Plexus
Osteogenic Sarcoma
Glioma Susceptibility 1
Basal Cell Carcinoma 7
Adrenocortical Carcinoma, Hereditary
Bone Marrow Failure Syndrome 5
Pancreatic Cancer
Leukemia, Chronic Lymphocytic
Choroid Plexus Cancer
Hepatocellular Carcinoma
Nasopharyngeal Carcinoma
Bone Osteosarcoma
Li-Fraumeni Syndrome 1
Colorectal Cancer
Squamous Cell Carcinoma
Rhabdomyosarcoma
Sarcoma
Gallbladder Cancer
Plasma Cell Neoplasm
Anaplastic Astrocytoma
Thyroid Gland Anaplastic Carcinoma
Malignant Astrocytoma
Ductal Carcinoma in Situ
Cervix Carcinoma
Breast Adenocarcinoma
Tongue Disease
Pleomorphic Xanthoastrocytoma
Congenital Fibrosarcoma
Adrenal Cortical Carcinoma
Cervical Cancer
Lip and Oral Cavity Cancer
Diffuse Large B-Cell Lymphoma
Lymphoma, Hodgkin, Classic
Atypical Teratoid Rhabdoid Tumor
Lung Sarcomatoid Carcinoma
High-Grade Astrocytoma
Small Cell Cancer of the Lung
Lung Cancer Susceptibility 3
Embryonal Rhabdomyosarcoma
Pleomorphic Rhabdomyosarcoma
Myeloma, Multiple
Hepatoblastoma
Pancytopenia
Acute Megakaryocytic Leukemia
Squamous Cell Carcinoma, Head and Neck
Bladder Cancer
Esophageal Cancer
Rhabdomyosarcoma 2
Thyroid Cancer, Nonmedullary, 1
Hereditary Breast Ovarian Cancer Syndrome
Lymphoma, Non-Hodgkin, Familial
Ovarian Cancer
Conn's Syndrome
Lung Cancer
Gastric Cancer
Prostate Cancer
Leukemia, Acute Myeloid
Diamond-Blackfan Anemia
Diamond-Blackfan Anemia 1
Adenocarcinoma
Ovarian Serous Cystadenocarcinoma
Pancreatic Adenocarcinoma
Diffuse Pediatric-Type High-Grade Glioma, H3-Wildtype and Idh-Wildtype
Small-Cell Carcinoma of the Ovary of Hypercalcemic Type
Uterine Carcinosarcoma
Adenoid Cystic Carcinoma
Gliosarcoma
Lung Oat Cell Carcinoma
Bladder Urothelial Carcinoma
Suppression of Tumorigenicity 12
Giant Cell Glioblastoma
Skin Melanoma
Skin Squamous Cell Carcinoma
Brain Cancer
Brain Stem Glioma
Adult Hepatocellular Carcinoma
Head and Neck Cancer
Lung Squamous Cell Carcinoma
Lymphoma
Gastric Adenocarcinoma
Essential Thrombocythemia
Renal Cell Carcinoma, Papillary, 1
Glioblastoma
B-Lymphoblastic Leukemia/lymphoma with T(9;22)(q34.1;q11.2)
Medulloblastoma
Neuroblastoma
Myelodysplastic Syndrome
Renal Cell Carcinoma, Nonpapillary
应用领域
胰腺癌
癌症、肿瘤等研究
