智鼠故事 
C57BL/6JCya-Aco1em1flox/Cya 条件性基因敲除小鼠
基本信息
品系名称
C57BL/6JCya-Aco1em1flox/Cya
品系编号
CKOCMP-11428-Aco1-B6J-VA
产品编号
S-CKO-00968
基因名
Aco1
小鼠表型
基因别称
Irp1，Aco-1，Irebp
品系背景
C57BL/6JCya
修饰方式
条件性基因敲除
品系描述
Aco1位于小鼠的4号染色体，采用CRISPR/Cas技术，设计sgRNA和ssDNA，通过高通量电转受精卵方式，获得Aco1基因条件性敲除小鼠，性成熟后取精子冻存。
相关疾病：
Friedreich Ataxia
Hemochromatosis, Type 1
Iron Metabolism Disease
Ehrlichiosis
Anemia, Sideroblastic, 1
Hyperferritinemia with or Without Cataract
Spastic Paraplegia 38, Autosomal Dominant
Infantile Cerebellar-Retinal Degeneration
Iron Deficiency Anemia
Restless Legs Syndrome
Febrile Seizures, Familial, 1
Anemia, Sideroblastic, and Spinocerebellar Ataxia
Porphyria Cutanea Tarda
Beta-Thalassemia
Autosomal Recessive Cerebellar Ataxia
Neurodegeneration with Brain Iron Accumulation 3
Microcytic Anemia
Protoporphyria, Erythropoietic, 1
Hypochromic Microcytic Anemia
Erythrocytosis, Familial, 2
Deficiency Anemia
Metal Metabolism Disorder
Primary Polycythemia
Wolfram Syndrome 2
Cataract
Hereditary Ataxia
Cerebellar Disease
Neurodegeneration with Brain Iron Accumulation
Aceruloplasminemia
Parkinson Disease, Late-Onset
质控标准
精子检测
① 冷冻前验证精子活力观察
② 冷冻验证每批次进行复苏验证
品系状态
在研小鼠
环境标准
SPF
供应地区
全球范围
